ImmuneGuard - Immune Guard - The Ultimate Immune Protection

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Immune Guard Doctors

Recent studies from world pioneers in the area of tea research such as, Jack Bukowski, M.D., Ph.D. Harvard, and Fung Lung Chung, Ph.D. Institute of Cancer Prevention, Georgetown University, indicate that L-Theanine, an amino acid unique to tea and, polyphenols, particularly EGCG, are key weapons in the fight againstt the flu, colds, and viruses that are costing Americans billions of dollars in health care, pain and suffering, and lost wages. It is the research from these experts, among others, that led to the development of ImmuneGuard - the ultimate immune protection for the 21st century.

In its quest to find the ultimate immune enhancing formula, representatives from ImmuneGuard met with and interviewed 13 different research scientists from Harvard, Columbia, Rutgers, BYU, University of Minnesota, National Institute of Health, The Institute of Cancer Prevention, and other leading institutions to discuss the latest findings on tea research. These scientists, with over 300 combined years experience and thousands of published articles, concluded that tea extracts, such as EGCG and L-Theanine were very effective relieving the symptoms of a cold or flu.

The world’s foremost experts on the health benefits of tea concluded that the tea extracts found in ImmuneGuard are extraordinarily beneficial for your health. Many of the studies indicated that to receive the full benefits from tea, you must drink as much as 10-16 cups per day. Since most people will not drink that much tea in one day, ImmuneGuard was created to provide the benefits of tea including concentrated extracts, such as L-Theanine and EGCG, which substitutes for drinking many cups of tea. For most people, due to a very busy, hectic schedule, it is simply easier to take two capsules of ImmuneGuard per day. It is much easier to take ImmuneGuard than brewing tea, requires no sweeteners, is less expensive, and, since ImmuneGuard comes in a convenient bottle, it can be taken anywhere.

Modern science has confirmed the positive effects of tea extracts in ImmuneGuard contribute to overall good health. ImmuneGuard contains a variety of components that are beneficial to one's health. These include theanine (an amino acid unique to tea), antioxidants (polyphenols), vitamins, and minerals.

Biographical Sketch of Dr. Bukowski

JACK F. BUKOWSKI

Education:
1976 B.A. Johns Hopkins University, Baltimore, MD (Biology)
1984 Ph.D. University of Massachusetts School of Medicine, Worcester, MA (Immunology)
1989 M.D. University of Massachusetts School of Medicine,
Worcester, MA

Postdoctoral Training:
Internship and Residencies:
1989-1990 Intern in Medicine, New England Deaconess Hospital, Boston, MA
1990-1992 Resident in Medicine, New England Deaconess Hospital, Boston, MA

Clinical and Research Fellowships:
1984-1985 Research Fellow in Immunology, University of Massachusetts School of Medicine, Ray Welsh, Ph.D. Lab Chief.
1985-1988 Research Fellow in Immunology, University of Massachusetts School of Medicine, Ray Welsh, Ph.D. Lab Chief (part time while in medical school)
1988-1989 Research Fellow in Immunology, University of Massachusetts School of Medicine, Frank Ennis, M.D. Lab Chief (part time)
1992-1995 Clinical Fellow, Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA
1992-1995 Research Fellow in Medicine, Harvard Medical School, Boston, MA, Michael Brenner, M.D. Sponsor

Licensure and Certification:
1991 Massachusetts License Registration
1992 ABIM Certificate, Internal Medicine
1996 ABIM Certificate, Rheumatology

Academic Appointments:
1984-1986 Instructor in Microbiology, University of Massachusetts School of Medicine
1995-1999 Instructor in Medicine, Harvard Medical School and Brigham and Women's Hospital
2000- Assistant Professor of Medicine, Harvard Medical School and Brigham and Women's Hospital

Hospital Appointments:
1992-1996 Associate Rheumatologist, Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA

1997- Associate Physician, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, MA

Other Professional Positions:
2000- Regional Medical Director, Procter & Gamble Pharmaceuticals

Memberships in Professional Societies:
1997- American College of Rheumatology
2003- American Society for Bone and Mineral Research

Editorial Boards:
1984-pres Ad hoc reviewer for The Journal of Immunology, Journal of Experimental Medicine, Journal of Virology, Arthritis and Rheumatism, Blood
Study Sections:
1999-2001 Arthritis Foundation Study Section: Clinical Immunology

Awards and Honors:
1983 First Place, University of Massachusetts School Medicine Graduate Research Presentations

Current Research Interests:
1. The role of gd T cells in human and primate immunity to viral and bacterial infections (PI).
2. Recognition of alkylamine and bisphosphonate antigens by human gd T cells (PI).
3. Effect of alkylamine antigen consumption on human gd T cells (PI).
4. Role of gd T cells in tumor immunity and osteoporosis (PI)

Teaching:
Medical School Courses:
1984-1986 University of Massachusetts Medical School; Medical Microbiology Laboratory; Instructor; 100 medical students; 2 hours of preparation and 4 hours of instruction each week for 12 weeks each year
1992-1995 Harvard Medical School; Introduction to Clinical Medicine; Instruct 2 medical students for 4 hours once each year in musculoskeletal exam

Thesis Defense Committees
1996, 1998, 1999
Outside expert in Ph.D. thesis defense committee,
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School in viral immunology

Laboratory supervisory duties:
1999-2000 Supervise 3 postdoctoral fellows and one technician to carry out basic science research projects (10 hrs per week)
Organize and supervise weekly interlaboratory meeting in Lymphocyte Biology Section (3 hours per week)

Trainees:
1999-2002 Lisheng Wang, M.D., Ph.D., Postdoctoral Fellow

2000-pres Hiranmoy Das, Ph.D., Postdoctoral Fellow
Arati Kamath, Ph.D., Postdoctoral Fellow

Invited Presentations:
1983 Oral presentation of research at FASEB workshop
1994 Workshop speaker at Keystone Symposium
1995 Immunology seminar at University of Massachusetts Medical School
Rheumatology Grand Rounds at Boston University School of Medicine
1996 Rheumatology Grand Rounds at University of Massachusetts Medical School
1997 Rheumatology Grand Rounds at University of Pennsylvania School of Medicine
1998 Immunology Seminar, University of Rochester School of Medicine
Plenary session abstract, American College of Rheumatology Basic Science Symposium
Rheumatology Grand Rounds at Washington University School of Medicine
2000 Joint BWH/DFCI Immunology Seminar series, DFCI
18th Congress of Biochemistry and Molecular Biology, Birmingham, UK
2001 Rheumatology Grand Rounds at BWH
Rheumatology Grand Rounds at Beth Israel Deaconess
Endocrinology Seminar, Hospital for Special Surgery
Endocrine Grand Rounds at Mt. Sinai Hospital
2002 Grand Rounds Mt. Auburn Hospital
Hospital for Special Surgery Bone Club

Biographical Sketch of Dr. Chung

Fung-Lung Chung, Ph.D.

Position Title: Professor, Department of Oncology

Education/Training :
Institution and Loaction Degree:
Chung-Yuan College of Sciences & Engineering, Taiwan B.S. 1968-1971 Bio-organic Chemistry
University of Utah, Salt Lake City, UT Ph.D. 1973-1978 Medicinal Chemistry

Professional Positions:
2004-present Georgetown University Lombardi Comprehensive Cancer Center, Washington DC - Professor
1980-2004 American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, N.Y. - Chief, Division of Carcinogenesis and Molecular Epidemiology (1995-present); Associate Chief, Division of Chemical Carcinogenesis (1990-1995); Head, Section of Nucleic Acid Chemistry, Division of Chemical Carcinogenesis (1985-1990); Associate (1981-1984); Postdoctoral Fellow (1980-1981)
1993-present Memorial Sloan-Kettering Cancer Center, New York, N.Y., Adjunct Associate Member
1997-present New York Medical College, Adjunct Professor
1978-1980 Columbia University, New York, N.Y., Postdoctoral Fellow (1978-1979), Staff Associate (1979-1980)

Other Professional Activities and Honors:
1. Member of the NIH Scientific Review Committee, Chemical Pathology Study Section, Division of Research Grants, 1990-1994
2. Member of the NIH Review Committee for Program Projects: 1991-present
3. Member of Senior Advisory Committee, American Health Foundation, 1990-present
4. Co-Chair of the Mini-Symposium on Detection of DNA Adduct at the AACR Annual Meeting in Washington, DC, 1990
5. Co-Chair of the Poster Discussion Session on Dietary Carcinogenesis/Chemoprevention at the AACR Annual Meeting in San Diego, CA, 1992
6. Editorial Board of Chemical Research in Toxicology - 1994-1997
7. Editorial Board of Oncology Reports, an International Journal - 1993-1995
8. Editorial Member of Journal of Cellular Biochemistry, Chemoprevention Supplements, 1997-present
9. Lung Cancer Progress Review Group, National Cancer Institute, 2001

Selected Publications (from a total of 141 papers):
1. Chung, F.-L., Jiao, D., Yu, M., (1998), A urinary biomarker for total uptake of dietary isothiocyanates in humans, Cancer Epid. Bio. Prev., 7, 103-108.
2. Conaway, C.C., Jiao, D., Kelloff, G.J., Steele, V.E., Rivenson, A, Chung, F.-L., (1998), Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl)-retinamide, and b-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice, Cancer Letters, 124, 85-93.
3. Chen, H.-J. C., Gonzalez, F.J., Shou, M., Chung, F.-L., (1998), 2,3-Epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase, Carcinogenesis, 19, 939-943.
4. Jiao, D., Yu, M.C., Hankin, J.H., Low, S.-H, Chung, F-L., (1998), Total isothiocyanate contents in cooked vegetables frequently consumed in Singapore, J. Agric. Food Chem., 46, 1055-1058.
5. Seow, A., Shi, C.-Y., Chung, F.-L., Jiao, D., Hankin, J.H., Lee, H.-P., Coetzee, G.A., Yu, M. (1998), Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: Relationship with dietary total ITC and glutathione s-transferase M1/T1 genotypes, Canc. Epid., Bio. Prev., 7, 775-781.
6. Chung, F.-L., Wang, M., Rivenson, A., Iatropoulos, M.I., Reinhardt, J., Pittman, B., Ho, C.-T., Amin, S.G., (1998), Inhibition of lung carcinogenesis by black tea in Fischer rats treated with tobacco-specific carcinogen: Caffeine as an important constituent, Cancer Res., 58, 4096-4102.
7. Conaway, C.C., Jiao, D., Kohri, T., Liebes, L., Chung, F.-L., (1998), Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats, Drug Metab. Dispos., 27, 13-20.
8. Chen, H.-J. C., Zhang, L, Cox, J., Cunningham, J.A., Chung, F.-L., (1998), DNA adducts of 2,3-epoxy-4-hydroxynonanal: Detection of 7-(1’,2’-dihydroxyheptyl)-3H-imidazo [2,1-i]purine and 1,N6-ethenoadenine by gas
chromatography/negative ion chemical ionization/mass spectrometry, Chem. Res. Toxicol., 11, 1474-1480.
9. Chung, F.-L., Nath, R.G., Nagao, M., Nishikawa, A., Zhou, G.-D., Randerath, K., (1999), Endogenous formation and significance of 1, N2-propanodeoxyguanosine adducts, Mut. Res., 424, 71-81.
10. Chung, F.-L., (1999), The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black tea. Proc. Soc. Exper. Biol. Med., 220, 244-248.
11. Getahun, S.M., Chung, F.-L., (1999), Conversion of glucosinolates to isothiocyanates in humans after ingesting cooked watercress, Canc. Epid., Bio. Prev., 8, 447-451.
12. Chung, F.-L., Zhang, L., Ocando, J.E., Nath, R.G., (1999), The role of 1,N2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans. In: Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis, 150th Edition, (Singer, B., Bartsch, H.) pp. 797-804, IARC Sci. Publ.
13. Chen, H.-J., Chiang, L.-C., Tseng, M.-C., Zhang, L.L., Ni, J., Chung, F.-L., (1999), Detection and quantification of 1,N6-ethenoadenine in human placenta DNA by mass spectrometry, Chem. Res. Toxicol., 12, 119-1126.
14. Chung, F.-L., Nath, R.G., Ocando, J.E., Nishikawa, A., Zhang, L., (2000), Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources, Cancer Res., 60, 1507-1511.
15. London, S.J., Yuan, J.-M, Chung, F.-L., Gao, Y.-T., Coetzee, G.A., Ross, R.K., Yu, M.C., (2000) Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and lung cancer risk: a prospective study of men in Shanghai, China, Lancet, 356, 724-729.
16. Chiao, J.W., Chung, F.-L., Krzeminski, J., Amin, S., Arshad, R., Ahmed, T., Conaway, C.C., (2000), Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate, Int. J. Oncol., 16, 1215-1219.
17. Chung, F.-L., Conaway, C.C., Rao, C.V., Reddy, B.S., (2000), Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate, Carcinogenesis, 21, 2287-2291.
18. Penn, A., Nath, R., Pan, J., Lung, C.-C., Widmer, K., Henk, W., Chung, F.-L., (2001), 1,N²-Propanodeoxyguanosine adduct formation in aortic DNA following inhalation of acrolein, Environmental Health Perspectives, 109, 219-224.
19. Liebes, L., Conaway, C. C., Hochster, H., Mendoza, S., Hecht, S.S., Crowell, J., Chung, F.-L., (2001), HPLC based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate, Anal. Biochem., 291: 279-289.
20. Chung, F.-L., (2001), Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mice, Exp. Lung Res., 27, 319-330.
21. Conaway, C.C., Getahun, S.M., Liebes, L.L., Pusateri, D.J., Topham, D.K.W., Botero-Omary, M., Chung, F.-L., (2001), Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli, Nutrition and Cancer, 38, 168-178.
22. Kohri, T., Nanjo, F., Suzuki, M., Seto, R., Matsumoto, N., Yamakawa, M., Hojo, H., Hara, Y., Desai, D., Amin, S., Conaway, C.C., Chung, F.-L., (2001), Synthesis of (-)-[4-3H]epigallocatechin gallate and its metabolic fate in rats after intravenous administration, J. Agric. Food Chem., 49, 1042-1048.
23. Conaway, C.C., Krzeminski, J., Amin, S., Chung, F.-L., (2001), Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome P450 isozymes. Chem. Res. Toxicol., 9, 1170-1176.
24. Yang, Y-M., Conaway, C.C., Chiao, J.W., Wang, C-X., Amin, S., Whysner, J., Dai, W., Reinhardt, J., Chung, F.-L., (2002), Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the post-initiation phase is associated with activation of MAP kinases and p53 activity and induction of apoptosis. Cancer Res., 62, 2-7.
25. Chiao, J.W., Chung, F.-L., Kancherla, R., Ahmed, T., Conaway, C.C., (2001), Sulforaphane and its metabolites as regulators of human prostate cancer cells in growth, development and apoptosis. Int. J. Oncol., 201:631-636.
26. Chung, F.-L., (2002) Dietary isothiocyanates: Roles in cancer prevention and metabolism in rodents and humans, In: Phytochemicals in Nutrition and Health: Proceedings from The Third International Conference on Phytochemicals: From Harvest to Health, (Meskin, M.S.), 87-104.
27. Hu, W., Feng, Z., Eveleigh, J., Iyer, G., Pan, J., Amin, S., Chung, F.-L., Tang, M-S., (2002), The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis, 23:1781-1782.
28. Fowke, J.H., Chung, F.-L., Jin, F., Qi, D., Cai, Q., Conaway, C., Cheng, J.-R., Shu, X-O, Gao, Y.-T., Zheng, W., (2003), Urinary isothiocyanate levels, brassica, and human breast cancer, Cancer Res., 63: 3980-3986.
29. Chung, F.-L., Schwartz, J., Herzog, C., Yang, Y-M. Tea and cancer prevention: Studies in animals and humans, J. Nutr., 133:3268S-3274S, 2003.
30. Chung, F.-L., Pan, J., Choudhury, S., Roy, F., Hu, W., Tang, M-S., (2003), Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from w-3 and w-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. Mutation Res., 531:25-36.
31. Zhang, L., F.-L. Chung, Boccia, L., Colosimo, S., Liu, W., Zhang, J., (2003), Effects of garage employment and tobacco smoking on breathing-zone concentrations of carbonyl compounds. AIHA, 64: 388-393.

C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal and non-federal support). Begin with the projects that are most relevant to the research proposed in this application. Briefly indicate the overall goals of the projects and responsibilities of principal investigator identified above.

RESEARCH PROJECTS ONGOING OR COMPLETED IN THE LAST THREE YEARS:

ONGOING - F.-L. Chung
RO1 CA 43159-14 Chung (PI)NCIEnals in Tumorigenesis 8/01/86 - 4/30/04$249,064 30%
This project focuses on studying (a) the roles of different types of polyunsaturated fatty acids (w-3 and w-6) in the formation of enal-derived cyclic DNA adducts in vitro and in vivo, including humans and (b) the development of a new sensitive method for the detection of other cyclic DNA adducts in vivo.

COMPLETED
PO1 CA 46535-13 (Hecht/Chung)NCIChemoprevention of Lung & Esophageal CancerProject 1: Conjugates of Isothiocyanates as Chemopreventive Agents 04/01/98-01/31/03$225,577 80%
This project focuses on the development of the thiol conjugates of isothiocyanates for chemoprevention of lung cancer, elucidating the relevant mechanisms of tumor inhibition. The conjugates are potentially better chemopreventive agents than the parent isothiocyanates. Their mechanisms appear to involve the equilibrium of the conjugates with parent compounds and thiols via a dissociation reaction.